Jane Vasko was an undercover police officer attempting to infiltrate a major New York City drug ring. After gaining the trust of the dealers, her cover was unknowingly blown and she was forced to submit to a drug cocktail that landed her in a coma - until one day she awoke to a world where nothing was the same! Infused somehow during her fitful sleep with strange powers, Jane has nothing left to lose and a whole lot of people to make pay for what they've done! The survivors of the nuclear fire called the war Judgment Day lived only to face a new nightmare: the war against the machines! Dynamite presents the four-issue crossover event pitting Painkiller Jane against the Terminators in New York City (along with some future Terminator action!)!

Manhattan, as you know it, is underwater. The government, in an effort to maintain the delicate balance between a growing population and dwindling food supplies, regulates childbirth rates in the few remaining cities. Those born illegally are hunted down and killed by lifeless corporate-sponsored machines programmed to perform the dirty work of their makers. The media embraces this law. The people embrace this law. The only opposition comes from those children whose lives are forfeit the moment they exist. What were once deadly street gangs, the poor and huddled masses have evolved into revolutionaries fighting for the basic human right to live.