Vurt tells the story of Scribble and his "gang", the Stash Riders, as they search for his missing sister Desdemona. The novel is set in an alternate version of Manchester, England, in which society has been shaped by Vurt, a hallucinogenic drug/shared alternate reality, accessed by sucking on colour-coded feathers. Through some (never explained) mechanism, the dreams, mythology, and imaginings of humanity have achieved objective reality in the Vurt and become "real".