The game takes place in a post-apocalyptic 28th century. In the mid-22nd century, tensions rose between an expanded Chinese Empire and a joint European/North American Federation of the Free World. The unexplained apparent destruction of the first Chinese interstellar colony ship results in China launching devastating nuclear strikes with stealth missiles. In retaliation, the President gives the command to counter strike with cold fusion long-range missiles. World War III starts on February 17, 2143; it lasts less than 6 hours.

Neocron 2: Beyond Dome of York is a 2004 video game which is a follow-up to 2002's Neocron. Originally slated to be an expansion pack, Neocron 2 was released separately under a new publisher, 10tacle Studios AG.