The story of Dreamfall is presented as a narration of Zoë Castillo, a 20-year-old resident of Casablanca in 2219, who lies in coma and recounts the events that led thereto. Her narration concerns Project Alchera, an international conspiracy by the Japan-based toy manufacturer WATIcorp, that aims to introduce a potentially-destructive lucid dream technology ("dreamer console") to the market. One byproduct of their research is Faith, a girl used for testing the hallucinogenic drug Morpheus, who upon dying thereof transferred her consciousness to the DreamNet mainframe computer Eingana. As a result, she appears on the Wire, causing white noise disrupting the infrastructure of Stark.

The protagonist and anti-hero is named Ryan, a bartender in a futuristic dystopian city (implied to be in England, as evidenced by the use of British English such as "lift" and "bonnet [of a car]") who has been plagued by strange dreams of an entity known as the Dreamweb. In the dream that opens the game, Ryan is asked by the master monk of the Keepers to be the deliverer and kill the seven evils, who are united to break the Dreamweb and send mankind spiraling into chaos. (In Diary of a (Mad?)man, however, which precedes the start of the game, it is strongly implied that Ryan is descending into psychosis and has fabricated the whole Dreamweb scenario in his mind.)

Speedball is a video game series based on a violent futuristic cyberpunk sport that draws on elements of handball and ice hockey, and rewards violent play as well as goals.