In a futuristic world where criminal intent is analyzed by the Sybil System, a new top of the class recruit, Akane Tsunemori, joins the police force; however, she always puts her own sense of justice above the judgment of Sybil. Police are helped by Enforcers (latent criminals disposed to high criminal intent), one of which is a former inspector who supports Akane's method of action.

In this sequel to Psycho-Pass TV show, Inspector Tsunemori is sent to a neighboring war-torn nation, where the Sibyl System is being introduced as an experiment, to find Shinya Kogami, her former enforcer who went rogue three years ago.