In the near future, crime is patrolled by a mechanized police force. When one police droid, Chappie, is stolen and given new programming, he becomes the first robot with the ability to think and feel for himself.

Two years after M3GAN's rampage, her creator, Gemma, resorts to resurrecting her infamous creation in order to take down Amelia, the military-grade weapon who was built by a defense contractor who stole M3GAN's underlying tech.

While attending a meeting as a Chief Inspector of the Public Security Bureau, Akane Tsunemori received a report that an incident had occurred on a foreign vessel, and this was the beginning of a big and unexpected case.