Set in a time when Sarajevo was obliterated by a homemade nuclear device, the story reflects a world inundated with genocide. An American man by the name of John Paul seems to be responsible for all of this and intelligence agent Clavis Shepherd treks across the wasteland of the world to find him and the eponymous "genocidal organ."

After the events of Psycho-Pass 3, Inspector Kei Mikhail Ignatov finds himself involved with an organization named Bifrost. First Inspector Koichi Azusawa coordinates an assault on the Public Safety Bureau tower.