Scandal-plagued hacker journalist John Hawke is hot on the trail of the explosive story that might save his career. James Weller, the former CEO of giant technology company Eclipse, has founded a new start-up, and he’s agreed to let Hawke do a profile on him. Hawke knows something very big is in the works at Eclipse---and he wants to use the profile as a foot in the door to find out more.

As a replicant, or “technohuman,” Detective Bruna Husky knows two things: humans bioengineered her to perform dangerous, undesirable tasks, and she has just ten years on the United States of Earth before her body automatically self-destructs. But with “antitechno” rage on the rise and a rash of premature deaths striking her fellow replicants, she may have even less time than she thought.

Los Angeles of 2039 is a baffling and bifurcated place. After the Collapse of 2028, a vast section of LA, the Disincorporated Zone, was disowned by the civil authorities, and became essentially a third world country within the borders of the city. Navigating the boundaries between DZ and LA proper is a tricky task, and there's no one better suited than eccentric private investigator Erasmus Keane. When a valuable genetically altered sheep mysteriously goes missing from Esper Corporation's labs, Keane is the one they call.