When Doc Ido, a talented cyber-physician, finds Alita's head in a junk heap, she has lost all memory of her past life. But when he reconstructs her, she discovers her body still instinctively remembers the Panzer Kunst, the most powerful cyborg fighting technique ever known. In the post-apocalyptic world of the Scrapyard, as the secrets of Alita's past unfold, each day is a struggle for survival.

Nanotechnology made humanity immortal, and the resulting population explosion pushed the Solar System’s resources to the breaking point. As a result, new births are banned and even the planets’ disparate governments cooperate to annihilate any children already born. With the tournament looming, Alita and her comrades find themselves caught between a spacefaring refuge for young innocents and a bloodthirsty mob intent on killing the children for sport!

On her way to retrieve Lou’s brain, Alita encounters a ghost from her past—an old mentor whose revelations shake Alita's very identity. Meanwhile Elf, Zwölf, and Sechs fight their deadly – and creepiest–enemies yet as the ZOTT rages on! But will the ARs have the mental fortitude to resist the psychically altered leader of the fearsome Starship Cult?

In the depths of Melchizedek, Alita inches closer to recovering her dear friend’s brain but not before she is greeted by Mbadi and a rather duplicitous Desty Nova doppleganger. Meanwhile, Sechs and the other members of the Space Angels make their way through ZOTT, where Sechs comes to face a universally renowned Space Karate master in a show of technique, toughness and…thumbs?

After nearly being canceled, the Z.O.T.T. resumes and now inches towards its conclusion with the Space Angels going head-to-head against new, formidable opponents that push their combative skills to the limit. With Alita jumping back into the fray, the independence of Tiphares and the scrapyard are depending on her victory, and with her new, seemingly unstoppable abilities, triumph seems to be nearly at hand for the Space Angels. However, behind the scenes, Mbadi and other nefarious entities are plotting to turn things around on Alita and her friends as the Z.O.T.T. continues into its final round.