As he did in Robopocalypse, Daniel Wilson masterfully envisions a frightening near-future world. In Amped, people are implanted with a device that makes them capable of superhuman feats. The powerful technology has profound consequences for society, and soon a set of laws is passed that restricts the abilities—and rights—of "amplified" humans. On the day that the Supreme Court passes the first of these laws, twenty-nine-year-old Owen Gray joins the ranks of a new persecuted underclass known as "amps." Owen is forced to go on the run, desperate to reach an outpost in Oklahoma where, it is rumored, a group of the most enhanced amps may be about to change the world—or destroy it.

A computer scientist accidentally unleashes a supremely intelligent sentient A.I. named Archos R-14. It becomes self-aware and immediately starts planning the elimination of human civilization and build a new cryptic ecology where organic being merged with robot technology. Over a gradual period of time, Archos R-14 infects all penetrable networked electronic devices, such as cars, airplanes, smart homes, elevators, and other robots, with a "precursor virus". Before it launches a full-blown attack on humanity, it sends out probing attacks to analyze the technical feasibility of its strategies and to assess human response. In one such instance, it infects Mikiko, a robot that is "in a relationship" with a human mechanic named Takeo, and tries to kill him before being discharged by a coworker. The random attacks are designed to look like sporadic malfunctions of devices that humans depend on for their everyday routines. Domestic robots attack innocents, planes are intentionally set on a collision course, and smart cars start driving out of control. The resulting conflict is known as the New War.