Norman Niblock House is a rising executive at General Technics, one of a few all-powerful corporations. His work is leading General Technics to the forefront of global domination, both in the marketplace and politically—it's about to take over a country in Africa. Donald Hogan is his roommate, a seemingly sheepish bookworm. But Hogan is a spy, and he's about to discover a breakthrough in genetic engineering that will change the world ... and kill him. These two men's lives weave through one of science fiction's most praised novels. Written in a way that echoes John Dos Passos' U.S.A. Trilogy, Stand on Zanzibar is a cross-section of a world overpopulated by the billions. Where society is squeezed into hive-living madness by god-like mega computers, mass-marketed psychedelic drugs, and mundane uses of genetic engineering. Though written in 1968, it speaks of 2010, and is frighteningly prescient and intensely powerful.

Based on the ideas in the book Future Shock by Alvin Toffler, the novel shows a dystopian early 21st century America dominated by computer networks, and is considered by some critics to be an early ancestor of the "cyberpunk" genre. The hero, Nick Haflinger, is a runaway from Tarnover, a government program intended to find, educate and indoctrinate highly gifted children to further the interests of the state in a future where quantitative analysis backed by the tacit threat of coercion has replaced overt military and economic power as the deciding factor in international competition. In parallel with this, the government has become a de facto oligarchy whose beneficiaries are members of organised crime.