Set in the future, the plot follows Zoichi Kanoe and his AI companion Fuyu Kanoe, whose luminous form is integrated into the system of his motorcycle. They are agents sent by TOA Heavy Industries to retrieve humans with the ability to resist and transmute the N5S infection, which is spreading across the world, turning humans into "Drones"; disfigured, zombie-like beings.

Within a claustrophobic, tech-drenched megastructure that encompasses the entire planet, Killy, a traveler with a small but super powerful gun, silently traverses countless levels of what is called “The City.” He’s searching for “net terminal genes” which may allow him to connect with The City’s neural center and stop its growth. Along the way he meets various transhuman inhabitants, but is also pursued by The City’s cyborg defenses. A prequel, NOiSE, was released in 2001, and a sequel, NSE: Net Sphere Engineer, began in 2004. A 6-part original video animation based on the comic was released in 2003.

BLAME! Academy and So On is a spin-off series of BLAME! set in the same "City" as BLAME! and is a parody / comedy about various characters in the main BLAME! storyline set in a traditional Japanese school environment. Various elements of the main BLAME! story are parodied, including the relationship between Killy and Cibo, and Dhomochevsky and Iko. Irregularly published in Afternoon and compiled as BLAME! Gakuen and So On September 19, 2008, this is its first official English language release in either digital or print.

In a dark, dystopic future, the Church of Transfiguration was formed; their charter was to promote extreme cybernetic enhancements. However, mankind also perfected the art of immortality through genetic manipulation, and then the great ruin came. Now, the Church sends its Inquisition to track down these genetically modified beings, and the only one who is seemingly able to stand in their way is Digimortal, a deadly, violent mercenary...

A Sci-Fi Adventure Set in the BLAME! Universe As detective Musubi Susono investigates a series of child kidnappings, her own partner is viciously murdered. But when the investigation takes a brutal turn, she is suddenly confronted by the killer--and his vicious Silicon Creature...

A one-shot sequel to Blame!

Marvel Manga action by Japanese superstar Tsutomu Nihei! Alone in a barren wasteland inhabited by robotic, parasitic organisms, the X-Men's most lethal member devolves further and further into his true, savage, berserker state with each battle. The key to Logan maintaining a link to his humanity may lie with a mysterious young girl.