In William Gibson's first novel since 2014's New York Times bestselling The Peripheral, a gifted "app-whisperer" is hired by a mysterious San Francisco start-up and finds herself in contact with a unique and surprisingly combat-savvy AI.

The book has three separate but overlapping stories, with the repeated appearance of shared characters. The San Francisco/Oakland Bay Bridge, the overarching setting of the trilogy, functions as a shared location of their convergence and resolution.

The U.S. political leaders of 2016 abandon the radioactive planet they've destroyed and harness the power of humanity's last hope: The Splitter, a colossal machine designed to manufacture a bright new reality for them to infiltrate and corrupt.

A military pilot from a radioactive, alternate future has arrived in Berlin 1945, and the corrupt officials from his world want him stopped. Though he won't reveal the details of his mission, he's made one thing clear: our entire reality is at stake.

Mr. Baby—a bizarre looking, dangerous man—is the sole survivor of Berlin's prewar nightlife. Play by his rules, and he can get you anything, but he's not one to be crossed. A hard lesson for our inter-dimensional pilot… and the corrupt officials from his world who want him dead.

Time is running out. Corrupt, otherworldly political powers threaten to hijack our reality, and they have the nuclear capabilities needed to alter the course of our history forever. One lone pilot and those who dare to trust him are all that stand in the way of a radioactive future.

Aboard a B-29 bomber soaring high over Europe, the Vice-President of a radioactive America one reality removed from our own is about to nuke all of history as we know it. This is the end.

"Burning Chrome" tells the story of two free-lance hackers - Automatic Jack, the narrator and a hardware specialist; and Bobby Quine, a software expert. Bobby becomes infatuated with a girl named Rikki and wants to become wealthy in order to impress her. Jack has acquired a powerful Russian "icebreaker" program that can penetrate corporate security systems. Bobby suggests that they use it to break into the system of a notorious and vicious criminal known as Chrome, who handles money transfers for organized crime, and Jack reluctantly agrees to help. The break-in is successful, and Jack and Bobby empty Chrome's bank accounts, but they discover afterward that Rikki had been working in a brothel with ties to Chrome. She uses her earnings to buy a set of cybernetic eye implants for herself and go to Hollywood; the news leaves both men devastated, as they have grown to love her, and Jack never sees her again.

Seven years after the events of Neuromancer, strange things begin to happen in the Matrix, leading to the proliferation of what appear to be voodoo gods (hinted to be the fractured remains of the joined AIs that were Neuromancer and Wintermute). Two powerful multinational corporations, Maas Biolabs and Hosaka, are engaged in a battle for control over a powerful new technology (a biochip), using hackers and the Matrix as well as espionage and violence.

In the post Tokyo/San Francisco earthquake world of the early 21st century, Colin Laney is referred to agents of the aging mega-rock star Rez of the musical group Lo/Rez for a job using his peculiar talent of sifting through vast amounts of mundane data to find "nodal points" of particular relevance. Rez has claimed to want to marry a synthetic personality named Rei Toei, the Idoru (Japanese Idol) of the title, which is apparently impossible and therefore questioned by his loyal staff, particularly by his head of security, Keith Blackwell. Blackwell believes that someone is manipulating Rez, and wants Laney to find out who. Simultaneously, the Seattle chapter of the Lo/Rez fan club is discussing exactly the same topic of the unbelievable marriage of human and AI construct. Fourteen-year-old Chia Pet McKenzie is chosen by the group to go to Tokyo and meet with the Tokyo chapter to find out what is really happening. On the flight she meets a woman named Maryalice, who dupes her into unwittingly carrying a contraband item through customs in Tokyo.

Johnny is a courier. He carries other people's memories, millions of them, downloaded into his brain... Working out of Beijing, he is hired to carry a package to the States. The hundreds of gigabytes stashed in his head are far beyond his capacity, but as long as he gets downloaded quickly they won't do him any permanent harm...

Taking place eight years after the events of Count Zero and fifteen years after Neuromancer, the story is formed from several interconnecting plot threads, and also features characters from Gibson's previous works (such as Molly Millions, the razor-fingered mercenary from Neuromancer). One of the plot threads concerns Mona, an innocent young prostitute who has a more-than-passing resemblance to famed Simstim superstar Angie Mitchell. Mona is hired by shady individuals for a "gig" which later turns out to be part of a plot to abduct Angie.

Henry Dorsett Case is a low-level hustler in the dystopian underworld of Chiba City, Japan. Once a talented computer hacker, Case was caught stealing from his employer. As punishment for his theft, Case's central nervous system was damaged with a mycotoxin, leaving him unable to access the global computer network in cyberspace, a virtual reality dataspace called the "Matrix". Unemployable, addicted to drugs, and suicidal, Case desperately searches the Chiba "black clinics" for a miracle cure. Case is saved by Molly Millions, an augmented "street samurai" and mercenary for a shadowy ex-military officer named Armitage, who offers to cure Case in exchange for his services as a hacker. Case jumps at the chance to regain his life as a "console cowboy," but neither Case nor Molly knows what Armitage is really planning. Case's nervous system is repaired using new technology that Armitage offers the clinic as payment, but he soon learns from Armitage that sacs of the poison that first crippled him have been placed in his blood vessels as well. Armitage promises Case that if he completes his work in time, the sacs will be removed; otherwise they will dissolve, disabling him again. He also has Case's pancreas replaced and new tissue grafted into his liver, leaving Case incapable of metabolizing cocaine or amphetamines and apparently ending his drug addiction.

The comic adaptation of Gibson’s groundbreaking novel which put cyberpunk on the map. After a condition renders him unable to access cyberspace, Case, an out-of-work, drug-addled hacker, is hired by a mysterious patron who promises to cure him. They also enlist Molly Millions, a “razorgirl” with extensive body modifications, who helps them take on entrenched corporate syndicates as well as a powerful article intelligence. The comic only covered the book’s first two chapters before it was discontinued.

The story follows two corporate extraction agents, who perform the new version of corporate espionage, grabbing scientists and engineers from rival firms. Given the level of protection offered, extracting them from a company is a highly dangerous affair. In the story, the narrator and his partner Fox have joined up with a new associate, Sandii, in an attempt to extract an extremely talented biologist from a hot new German research company. The company's security is superb, and the attempt takes considerable time to plan.

Advertising consultant Cayce Pollard, who reacts to logos and advertising as if to an allergen, arrives in London in August 2002. She is working on a contract with the marketing firm Blue Ant to judge the effectiveness of a proposed corporate logo for a shoe company. During the presentation, graphic designer Dorotea Benedetti becomes hostile towards Cayce as she rejects the first proposal. After dinner with some Blue Ant employees, the company founder Hubertus Bigend offers Cayce a new contract: to uncover who is responsible for distributing a series of anonymous, artistic film clips via the internet. Cayce had been following the film clips and participating in an online discussion forum theorizing on the clips' meaning, setting, and other aspects. Wary of corrupting the artistic process and mystery of the clips, she reluctantly accepts. Cayce is not entirely comfortable with Ivy's chat group called "Fetish:Footage:Forum" (or F:F:F), as shown by the following excerpt:

Skinner's Room is a short story by William Gibson originally composed for Visionary San Francisco, a 1990 museum exhibition exploring the future of San Francisco. It features the first appearance in Gibson's fiction of "the Bridge", which Gibson revisited as the setting of his acclaimed Bridge trilogy of novels. In the story, the Bridge is overrun by squatters, among them Skinner, who occupies a shack atop a bridgetower. An altered version of the story was published in Omni magazine and subsequently anthologized. "Skinner's Room" was nominated for the 1992 Locus Award for Best Short Story.

The first strand of the novel follows Hollis Henry, a former member of the early 1990s cult band The Curfew and a freelance journalist. She is hired by advertising mogul Hubertus Bigend to write a story for his nascent magazine Node (described as a European Wired) about the use of locative technology in the art world. Helped by curator Odile Richard she investigates Los Angeles artist Alberto Corrales, who recreates virtually the deaths of celebrities such as River Phoenix. Corrales leads her to Bobby Chombo, an expert in geospatial technologies who handles Corrales' technical requirements. Chombo's background is troubleshooting navigation systems for the United States military. He is reclusive and paranoid, refusing to sleep in the same GPS grid square on consecutive nights, and only consents to talk to Hollis due to his admiration for The Curfew.

1855: The Industrial Revolution is in full and inexorable swing, powered by steam-driven cybernetic Engines. Charles Babbage perfects his Analytical Engine and the computer age arrives a century ahead of its time. And three extraordinary characters race toward a rendezvous with history - and the future: Sybil Gerard - dishonored woman and daughter of a Luddite agitator; Edward "Leviathan" Mallory - explorer and paleontologist; Laurence Oliphant - diplomat and spy. Their adventure begins with the discovery of a box of punched Engine cards of unknown origin and purpose. Cards someone wants badly enough to kill for...

The novel begins sometime in the near-future in a small town in rural America. Flynne Fisher works at a local 3D printing shop and lives with her mother and her brother Burton, who sustained brain trauma from cybernetic implants he received while serving in the US military's Haptic Recon unit. When Burton heads to another town to counter-protest the protests of a religious extremist group known as Luke 4:5 (similar to the modern day Westboro Baptist Church), he asks her to take over his job working security in a video game/virtual world for a supposedly Colombian company called Milagros Coldiron. Flynne takes the job and notices the game world looks suspiciously like London, but far more empty and more futuristic. Piloting a security quadrocopter, she fends off paparazzi drones from an unknown woman's high-rise apartment, but on the second night of doing so she witnesses a man lock the woman out on her balcony where she is gruesomely devoured by a swarm of nanobots.

The plot centers around Chevette Washington, a young bicycle messenger who lives in the ad hoc, off-the-grid community that has grown on the San Francisco-Oakland Bay Bridge in the aftermath of a devastating earthquake. Chevette, on a whim, steals a pair of dark-rimmed glasses from a man at a party because she is offended by his demeanor. Soon after, she realizes that the glasses have unlikely importance, as security company henchmen begin tracking and following her. Among the pursuers are Svobodov and Orlovsky, two Russian immigrants who reside in San Francisco and are employed as cops, as well as Loveless, a ruthless corporate hitman with gold incisors. The glasses contain plans by a powerful corporation to rebuild San Francisco entirely using nanotechnology, and for that reason, they are highly coveted and present a danger to the person who possesses them.