This novel's setting is a posthuman future, in which transhumanism long ago (during the mid 21st century) became the default philosophy embraced by the vast majority of human cultures.

Distraction opens during the election year of 2044 and drops us immediately into the hyperactive universe of Oscar Valparaiso, a fixer and political spin artist who has just conducted his first successful senatorial campaign and has been "rewarded" with a patronage position on the Senate Science Committee. His new job sends him to the backwaters of East Texas to investigate conditions in a federally funded research institute called the Collaboratory. Once there, he uncovers a long-standing history of kickbacks, corruption, and old-fashioned political featherbedding. Oscar's attempts to introduce an element of reform into this closed society lead directly to the two relationships that stand at the heart of the novel. One is a romantic liaison between Oscar and with Dr. Greta Penninger, a Nobel Prize-winning pioneer in the increasingly prominent field of neural studies. The other is a protracted, no-holds-barred conflict with the governor of Louisiana, a classic southern demagogue named Etienne (Green Huey) Hugelet, who has his own undisclosed interests in the products of theCollaboratory'sresearch.