Appleseed takes place in the 22nd century, after the non-nuclear Third World War has decimated the Earth. While countries like Great Britain, USA and China have difficulty maintaining order and power, international organizations like the "Sacred Republic of Munma" and "Poseidon" have been established in the aftermath.

The series involves the adventures of the Knight Sabers, an all-female group of mercenaries who don powered exoskeletons and fight various problems, most frequently rogue robots. The success of the series spawned several sequel series.

Nathan Never is an Italian monthly comic that follows an agent of Agenzia Alfa, a corporate law enforcement agency. Nathan Never patrols The City, a towering urban center that’s home to all classes of people, mutants, and robots. The series is largely made up of episodic stories, although there are recurring plotlines and an overall continuity. Legs Weaver, Nathan’s first partner, starred in her own eponymous spinoff comic that ran from 1994–2005, and graphic novels about various Agenzia Alfa members have been published biannually since 1994.