Global unrest spreads as mass protests advance throughout the US and China, Nexus-upgraded riot police battle against upgraded protestors, and a once-dead scientist plans to take over the planet's electronic systems. The world has never experienced turmoil of this type, on this scale.They call them the Apex - humanity's replacement. They're smarter, faster, better. And infinitely more dangerous.

Six months have passed since the release of Nexus 5. The world is a different, more dangerous place. In the United States, the terrorists – or freedom fighters – of the Post-Human Liberation Front use Nexus to turn men and women into human time bombs aimed at the President and his allies. In Washington DC, a government scientist, secretly addicted to Nexus, uncovers more than he wants to know about the forces behind the assassinations, and finds himself in a maze with no way out.

In the near future, the experimental nano-drug Nexus can link humans together, mind to mind. There are some who want to improve it. There are some who want to eradicate it. And there are others who just want to exploit it.