Keiko "Kei" Springs is a Rider, a specialized form of delivery girl and mercenary all in one. They are among the most highly prized criminals in the dystopian neon city of New Los Angeles. Kei has been running from her past for years and has literally erased it from her mind using a popular street drug called lethe. Unfortunately, you can't outrun your past forever, even on her specialized Nina cybercycle.

Ex-Rider Keiko "Kei" Springs was living with her adopted daughter Becky away from her previous life of crime. Unfortunately, the past is not easy to escape and her sadistic former sensei, Snake, gives her an ultimatum: perform eight tasks for him or die. The final mission before her freedom is nearly impossible, though. Snake wants her to take down a luxury resort where the super-rich are implanted with their heart's desires, only to be brainwashed into serial killers for blackmail potential.