After the happenings of Saints Row: The Third, the Saints gang extended their reach and the protagonist became the President of the USA. Unfortunately during a press conference, disaster happens: aliens attack the White House, kidnap the Saints and trap each in their personal, indefinitely looping nightmare. Fortunately Kinzie, the group's hacker, rescues the protagonist and together they flee into a space ship with the goal to rescue the rest of the gang. The majority of the game it spent in an open world simulation of Steelport, the location of Saints Row: The Third. There is an extensive character creation which allows to tune every aspect of the protagonist's look and the choice between seven voices (three male, three female and Nolan North).