The story follows Dex, a young woman living in Harbor Prime. Harbor Prime is a city controlled by corporations that are integrated into a secret authority known as the Complex. Dex becomes a target of the Complex that sends its assassins to her. Dex is saved by a hacker known as Raycast who guides her to safety. Raycast reveals that Dex is the "fragment of Kether." Kether was the supreme Artificial Intelligence program created by the Complex. It was shut down when the Complex lost control of it. Dex becomes part of resistance against the Complex.