Following a failed mission Off-world, the only two survivors of a combat squad, ex-marine Mead and Replicant combat model Six, have returned to Tokyo to search for the traitor who left them to die. Now working as unlicensed detectives while hunting their betrayer, Stix and Mead find themselves in the middle of a deadly conflict between rival Yakuza clans, Tyrell Corp special operatives, and Cheshire, an enigmatic rival to Tyrell with its own version of Replicant technology.