In Android Assault an alien species called the Xias have targeted human beings for extermination. They have assembled a massive fleet that has crushed any opposing ship that has been sent their way and has started to attacking colonies stationed on nearby planets with a collision course to Earth and it is up to the player to stop them. The gameplay is a side-scrolling shooter, similar to R-Type, where the player takes control of a space fighter that can morph into a cyborg called Bari-Arm and has an arsenal of weaponry to take down enemy ships including the Thundercracker, Burning Wave and the Chase Cannon along with picking up health and power-ups left behind by destroyed enemies

In the year 2056, a virus has appeared in the main defense computer of the planet Earth. The origin and nature of the virus is unknown. Scott O'Connor volunteers to undergo an experimental transfer technology that converts his brain into raw binary code. He takes on the image of a Kabuki dancer, since the computer recognizes his great-grandfather as one. The virus in the virtual world takes on properties of an actual virus-it leaves behind debris, mutant creatures, and parasite environments of a biological nature. At the final level, it is revealed that the virus is of alien origin, having been picked up by a lost Hyperion probe launched to a neighboring planet. O'Connor stops it before the virus can order the Hyperion to fire its laser weapons and destroy the human population.