Since the game is told as a series of flashbacks, it actually takes place in two different time frames. The current year is 2043, shortly after the events of The Pandora Directive and as such tensions between the Mutants and Norms have begun to die down. However, the flashbacks take place in November 2037. The Crusade for Genetic Purity is beginning to gain momentum, and tensions are building between the two groups. The Mutants are usually forced to live in the run-down areas of cities such as Old San Francisco. Tex lives in his new apartment on Front St. in New San Francisco. He has just been kicked out of the Colonel's Detective Agency for reporting the Colonel's unethical practices, and has now gone into business on his own.