The year is 2099. You're in London, but the world is different now. Thanks to the ramifications of global warming the world is now blanketed in dark clouds and rain constantly pours down without rest, creating a world very similar to that of Blade Runner.

Bionic Heart 2 begins right after one of the possible endings in the first game. Luke, Helen and Tom have escaped to a secret colony on mars while the fugitive cyborg Tanya remains on earth where she tries to bring and end to the powerful and corrupt Nanotech corporation. Meanwhile on Mars, where Luke has assumed the identity of a prominent scientist, he finds out that there might be more to the colony than it first seems.