It has been 73 years since Alex failed and the Humans lost the Cyborg Wars. Since then, the Humans have been enslaved. Scientists have developed a new DNA strain, which could signal the end of the Cyborgs, and they inject it into a volunteer.

Using footage left over from Nemesis 2 and a very thin story line sees Alex again fighting the cyborg mercenaries in 1998 East Africa.

It is the year 2077 and terrorist organization known as The Red Army Hammerheads now dominate the Earth. The fate of humanity now rests in the hands of The New Model, Ari Frost. Trained under the wing of Alex Rain, she must form an army of Cyborg Humans to take down the regime and regain control. After all, 86.5% is still considered human.