Tetsuya Azuma, also known as Casshern, is an android with a human consciousness, also known as a neoroider. Tetsuya turned himself into an android to hunt down and destroy the robots that have taken over the world.
A female scientist builds a humanoid robot detective (complete with human-like personality) to fight a band of murdering robots created and led by her crazed brother.
Somewhere in the future there is a computer project called Simulacron one of which is able to simulate a full featured reality, when suddenly project leader Henry Vollmer dies.