Los Angeles 2039. It has been three years since Niander Wallace introduced his brand of ‘perfectly obedient’ Replicants, and the ban on synthetic humans has been lifted, at least for the new Wallace models―the older Tyrell Corp’s Nexus 8 units are still hunted by Blade Runners. Cleo Selwyn, first seen as a small child in Blade Runner 2019, has returned to L.A. some twenty years later, searching for Isobel, a Replicant copy of her real mother who died when she was three. Cleo believes that Niander Wallace is holding Isobel captive, and the only person she can call on for help is the one who saved her so many years ago: Aahna ‘Ash’ Ashina, now an aging and disgraced ex-Blade Runner.

Lula Nomi is a Wiper--a private detective who guarantees complete discretion. A memory wipe after every job sees to that. When she's hired by enigmatic robot Klute, she thinks the case is the answer to all her problems. But there's something oddly familiar about Klute--and the more she investigates the disappearance of journalist Orson Glark, the more she suspects that he's somehow connected to her own past... Lula must face her greatest fears to learn what happened to Glark...and the truth about herself.