Los Angeles 2039. It has been three years since Niander Wallace introduced his brand of ‘perfectly obedient’ Replicants, and the ban on synthetic humans has been lifted, at least for the new Wallace models―the older Tyrell Corp’s Nexus 8 units are still hunted by Blade Runners. Cleo Selwyn, first seen as a small child in Blade Runner 2019, has returned to L.A. some twenty years later, searching for Isobel, a Replicant copy of her real mother who died when she was three. Cleo believes that Niander Wallace is holding Isobel captive, and the only person she can call on for help is the one who saved her so many years ago: Aahna ‘Ash’ Ashina, now an aging and disgraced ex-Blade Runner.

When a Tyrell Corporation scientist working on an experimental new type of Replicant is discovered dead in her laboratory, the victim of an apparent suicide, LAPD detective CAL MOREAU is called in to investigate. What he uncovers is a conspiracy of silence so deadly it could change the world as he knows it. Set ten years before the events of the first Blade Runner film, this is the world on the cusp of environmental collapse, and the beginning of the mass Off-world migration to the Off-world colonies. Through its rain-soaked streets, LAPD Detective CAL MOREAU, a PTSD sufferer, must travel as he attempts to unravel the truth behind a seemingly routine suicide that soon reveals itself to be just the thin end of a vast conspiracy, one that runs to the very top of the Tyrell Corporation tower.

LAPD detective CAL MOREAUX has teamed up with an escaped experimental REPLICANT, who has been uploaded with the memories of a dead Tyrell Corporation scientist, whose suicide he was sent to investigate. Now they must run and fight a conspiracy hatched in the very heart of the Tyrell Corporation.

Tyrell executive Ilora Stahl, head of a secret programme to transfer human consciousness into Replicant hosts has launched an all-out attack on Sector 6-b determined to flush out and kill a renegade Replicant called Nia, who was once part of her covert programme.