Los Angeles 2039. It has been three years since Niander Wallace introduced his brand of ‘perfectly obedient’ Replicants, and the ban on synthetic humans has been lifted, at least for the new Wallace models―the older Tyrell Corp’s Nexus 8 units are still hunted by Blade Runners. Cleo Selwyn, first seen as a small child in Blade Runner 2019, has returned to L.A. some twenty years later, searching for Isobel, a Replicant copy of her real mother who died when she was three. Cleo believes that Niander Wallace is holding Isobel captive, and the only person she can call on for help is the one who saved her so many years ago: Aahna ‘Ash’ Ashina, now an aging and disgraced ex-Blade Runner.

The second arc of Ash’s final adventure sees the retired Blade Runner reunited with Cleo Selwyn, her ward from the first Blade Runner graphic novel, 2019. Together they must go on the run from the deadly and fanatical LUV, the first Replicant Blade Runner seen in the movie Blade Runner 2049. It’s 2039 and Cleo Selwyn has finally returned to Los Angeles to search for her surrogate Replicant mother Isobel who Cleo believes has been abducted on the orders of Niander Wallace. Believing that Cleo’s DNA holds the secret of Replicant fertility Wallace has ordered his own personal assistant Replicant, Luv, the world’s first Replicant Blade Runner to hunt down and return Cleo to him and to kill all who stand in her way. Reuniting with former Blade Runner Aahna ‘Ash’ Ashina, Cleo and Ash set off on a road trip to find her mother with Luv hard on her heels.

In 2019, Aahna “Ash” Ashina was the LAPD’s most efficient and feared Blade Runner. Two decades later and Ash has lives ‘off-grid’ as fugitive outlaw helping Replicants escape their enslaved servitude and survive undetected on Earth. Now, in 2039, Niander’s own personal assistant, Luv, has become the first Replicant to be accepted into the Blade Runner unit, but she has a secret agenda, find Cleo, the daughter of industrialist Alexander Selwyn whom Ash helped to escape 20 years earlier. Now, as Ash’s past and future collide, her astonishing story finally concludes as she faces her greatest challenge saving the city she loves from the insane machinations of Niander Wallace, heir of the Tyrell empire. It's up to Ash to keep the truth about the Replicant miracle (seen in Blade Runner 2049) a secret, and to fulfill the pact she made years ago to those she loves most.