A mix of future tech and gothic vampire story, in the cyberpunk style, BloodNet puts the player into the role of a man named Ransom Stark, who must battle a vampire named Abraham Van Helsing who is attempting world domination and save both humanity and the cybernet. Ransom Stark was bitten by the aforementioned vampire, but is able to fight off the infection with the help of a computer grafted onto his brain stem. He must then embark on a journey to defeat the head vampire, Dracula, to stop the infection.

ARC agents Gideon Eshanti and Rachel Braque are spending the night together when they are attacked by a government execution squad. After killing the scrub agents, they flee to the apartment of Dante Scrivner. Dante offers them the use of his apartment, and says he'll use his connections to help investigate why the "The Hand of God", wants them dead. He also provides them a contact with the CFF, a rebel organization trying to overthrow the Hand of God, but they remain hopeful that they'll be able to clear their names instead.