The game is set in the year 2415, after disease has wiped out the majority of the Earth's population except for one walled and protected city-state, Bregna. The city is ruled by the congress of scientists who discovered the vaccine for the disease. When Aeon Flux, the player character and top operative in the underground "Monican" rebellion, is sent on a mission to kill a government leader (Trevor Goodchild) she uncovers a world of secrets which make her doubt her mission and question everything she thought she knew.

In COPS 2170, you take the role of rookie cop, Katrin, as she patrols the mean streets of a futuristic, cyberpunk metropolis. Katrin is a beautiful young, police academy graduate who is an excellent student and exceptional athlete. Unbeknownst to Katrin, her recent assignment concerning a series of terror attacks is about to propel her into the path of an evil genius. The game combines tactical strategy with RPG elements across 200 quests and 14 large maps.

Cyberpunk, mainly known by its second edition title Cyberpunk 2020, is a cyberpunk role-playing game written by Mike Pondsmith and published by R. Talsorian Games in 1988. Because of the release in 1990 of the second edition, set in a fictional 2020, the first edition is often now referred to as Cyberpunk 2013, following the fictional year, 2013, in which the game was set when it was first released in 1988. The third edition, published by R. Talsorian Games in 2005, is referred to as Cyberpunk V3.0 and is set further along the same fictional timeline as the former editions, during the 2030s.

Dealing with similar concepts to other incarnations of Ghost in the Shell, the game has an original storyline which follows on from and refers to the PlayStation 2 game's plotline.

The player assumes the role of Hunter, a computer expert who is hired by the Johnston Biotek corporation, referred to as the "Corporation" in the game. Hunter is to repair the network of a mining complex but fails and ends up in an underground cave world after an explosion. A man called Toadstool finds him and tells him where he is: In an underground world where a computer freak called Hacker has seized power. Left alone by the Corporation, Hunter has to find a way back to the surface all by himself. On his quest he meets Kathryn, a mysterious woman, who sometimes helps the player. Hunter faces many dangers and problems; for instance, when he is confronted by sinister figures in an underground prison colony.

Perfect Dark Zero is set in 2020 where a large percentage of the world is controlled by corporations. The most notable of these corporations are dataDyne, headed by Zhang Li, and the Carrington Institute, headed by Daniel Carrington. The player is cast as Joanna Dark, a bounty hunter working with her father Jack Dark and computer hacker Chandra Sekhar. The team is after Nathan Zeigler, an independent researcher who has been captured by a Hong Kong triad gang led by a man named Killian. Joanna and her father successfully rescue Zeigler, but Killian manages to escape. Zeigler explains that Killian was trying to obtain his research, which contains information about a dangerous weapon. As Zeigler refuses to go anywhere without his research, Joanna is sent to retrieve it while her father stays with Zeigler. After Joanna retrieved a case with Zeigler's research from a nearby safe house, Zeigler takes a device called neurodrive from the case and uses it to implant his research data into Jack's mind. Afterwards, Zeigler succumbs to his injuries sustained by Killian and dies. Before dying, Zeigler says that they must find a scientist named Dr. Eustace Caroll.

The game takes place in the year 2065 in Hong Kong. The city is suddenly attacked by a hostile force known as the Republic, led by a rogue Chinese general named Yan Lo. An international peacekeeping force stationed in Hong Kong, known as the Liberty Coalition, is tasked with defending the island from the invasion. The story follows Liberty Coalition 2nd Lieutenant Nathan Frost, who is critically injured in a surprise attack by the Republic while attempting to save the life of a wounded soldier. He is rebuilt by the Coalition using experimental nano-technology. Using the powers granted to him by his nano-technology augmentations, Frost spearheads the Coalition's counter-attack against the Republic, eventually rescuing a defecting Republic scientist named Dr. Joseph Liaw. Dr. Liaw informs Frost about a plot by General Yan Lo known as Project: Snowblind.

The player assumes the role of Anya Romanov, an acrobatic, high-tech professional thief living in the futuristic dark metropolis Forge City. Her initial mission is to infiltrate a high-security museum and steal items therein. Later on, Anya is framed for murder she did not commit. Eventually, she finds out about a sinister conspiracy involving a ruthless corrupt politician Richard Killian and her own deadly female ninja rival known only as Breeze.

In a world controlled by corporations, information is everything. Knowing that your competitors' secrets is the only way to get an edge in the cutthroat arena of corporate dominance. In this information age, warfare is carried out by "black hat" (morally corrupt) hackers who have become electronic gladiators for their boardroom puppet masters. You are a "white hat" hacker on the verge of being framed for a high-profile global cyber-crime. Your sophisticated program, designed to cleanse any network of malicious hacker activity, has been stolen by black hat hackers on the payroll of Globenet. A network of unscrupulous corporations. This evil alliance intends to use your code as a "logic bomb" to bring down rival corporations.

In The Matrix Online, the player assumes the role of a redpill, a human who was formerly trapped inside the Matrix and has since been freed and shown the truth of humanity's imprisonment. When creating a new character, the player is given the choice of taking a blue pill that will return them to their former life (quit the game) or a red pill, which will free their minds from the Matrix and allow them to take the body of a physical human and experience reality. Characters who are unaware of the fact that they are in the simulation are often referred to as "bluepills" because they have either taken the blue pill or have not been given the choice yet. People who are aware of the simulation (players) are referred to as "redpills" because they have taken the red pill (or, in very rare cases, when a character has self-substantiated out of the Matrix on their own). Following the choice between the two pills, the player is then taken through a basic tutorial of the game's mechanics, including mission interaction and the combat system. After the tutorial, they are then free to roam the Mega City (the large metropolis that the entire Matrix story is set in).

The Matrix: Path of Neo will follow the story of the blockbuster motion picture trilogy The Matrix, The Matrix Reloaded and The Matrix Revolutions and for the first time allow gamers to play as "Neo" and become "The One."

Utopia City is a sci-fi FPS game set in the year 2091, in a virtual world parallel to the real world.